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A Collection of Published Research Studies Using Homeoprophylaxis

A small listing of published research regarding homeoprophylaxis, more to come.
​Disclaimer: This is a topic of interest to me and this page is intended for information only. It does not constitute medical advise and is not meant to encourage or discourage the use of homeoprophylaxis or conventional immunization. 

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The Potential Value of Homoeoprophylaxis in Endemic and Epidemic Conditions

ABSTRACT:
Introduction: The term homoeoprophylaxis (HP) was first used by Burnett in 1884 to refer to medicines selected according to the Law/Principle of Similars to prevent targeted infectious diseases. HP medicines were first used by Hahnemann in 1798 and have been used since to protect significant numbers of people against a range of infectious diseases in many countries. This paper uses the results of a recent analysis of large HP interventions to assess the potential value of HP in epidemic and endemic conditions.

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The Potential Value of Homoeoprophylaxis in the LongTerm Prevention of Infectious Diseases, and the Maintenance of General Health in Recipients 

Dr. Isaac Golden, PhD thesis, Graduate School of Integrative Medicine Swinburne University of Technology . You can see and download the entire thesis here. Dr. Isaac Golden is recognized as a leading world authority on homeoprophylaxis. He discovered that HP not only is effective in the prevention of infections for which children receive vaccines, but that their health improved as a result of HP as the incidence of many common health problems, including eczema, asthma and behavioural concerns, was the lowest in the HP group, even lower than those of children not vaccinated or treated with HP. The vaccinated children were found to be the least healthy. 

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In Conversation with Dr. Rajesh Shah – The Developer of a COVID-19 Nosode

Dr. Rajesh Shah is interviewed by Ashok RajGuru about his new Covid 19 nosode, how it was tested, its efficacy and other nosodes he’s developed. The COVID-19 Nosode has been developed and has successfully completed Animal Toxicity Studies, Phase1 Human trial, Phase 2 Clinical trial, and more. This monumental work was undertaken by our guest for this interview – Dr Rajesh Shah. Dr. Shah has establish protocols for preparation, standardization, and in-vitro safety testing of nosodes. Read the whole article at Hpathy, here.

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Shah R. An experimental in vitro study to evaluate the antimalarial activity of select homeopathy preparations ISSN: 2454-9142, Impact Factor: RJIF 5.54. International Journal of Medical and Health Research. 2017 July; 3(7): p. 65-68.

Abstract

Malaria has become a public health concern worldwide. Although it is preventable and curable; P. falciparum and P. vivax have developed resistance to nearly all anti-malarial in current use.

New drug discovery and novel drug leads are required to control the current malaria disease burden. The inventor has developed malaria nosode and has subjected it for evaluation of antimalarial activity in vitro assay along with few other homeopathy preparations.

The potential antimalarial activity of the Malaria nosode, Malaria officinalis and China officinalis was evaluated by β-Hematin Formation Assay. The hemozoin content was determined by measuring the absorbance at 400 nm. The results were recorded as % inhibition of heme crystallization compared to negative control (DMSO)
Malaria nosode, Malaria officinalis and China officinalis exhibited inhibition of hemozoin and the inhibition was greater than the positive control Chloroquine diphosphate used in the study.

The study has shown anti-disease activity of an ultra-dilute (potentized) homeopathic preparation. The Malaria nosode prepared by potentizing Plasmodium falciparum organisms has demonstrated antimalarial activity, which supports the basic principle behind homeopathy, the law of similar. Read study here.

​Decreased Intensity of Japanese Encephalitis Virus Infection in Chick Chorioallantoic Membrane Under Influence of Ultradiluted Belladonna Extract

American Journal of Infectious Diseases 6 (2): 24-28, 2010 ISSN 1553-6203 © 2010 Science Publications 

​Abstract: Problem statement: No specific antiviral therapy is currently available despite an emergence and resurgence of Japanese encephalitis in South-East Asian Countries. There are only few recent studies, which were aimed to treat Japanese encephalitis with newer drugs. There is thus a real need for study on antiviral agents that can reduce the toll of death and neurological sequelae resulting from infection with this virus.

Approach: Optimum dilution of the JE virus was determined which could produce significant number of pocks on Chorioallantoic Membrane (CAM). Then ultradiluted belladonna preparations were used to see their inhibitory action on JE virus infection in CAM.

Results: Ultradiluted belladonna showed significantly decreased pock count in CAM in comparison to JE virus control.

Conclusion: Ultradiluted belladonna could inhibit JE virus infection in CAM, which may be mediated through glycosidase inhibitory role of calystegines present in belladonna. You can read the entire paper here.

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Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control

Homeopathy. 2010 Jul;99(3):156-66. doi: 10.1016/j.homp.2010.05.009.
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Bracho G, Varela E, Fernández R, Ordaz B, Marzoa N, Menéndez J, García L, Gilling E, Leyva R, Rufín R, de la Torre R, Solis RL, Batista N, Borrero R, Campa C.Author information

Abstract
BACKGROUND: Leptospirosis is a zoonotic disease of major importance in the tropics where the incidence peaks in rainy seasons. Natural disasters represent a big challenge to Leptospirosis prevention strategies especially in endemic regions. Vaccination is an effective option but of reduced effectiveness in emergency situations.

Homeoprophylactic interventions might help to control epidemics by using highly-diluted pathogens to induce protection in a short time scale. We report the results of a very large-scale homeoprophylaxis (HP) intervention against Leptospirosis in a dangerous epidemic situation in three provinces of Cuba in 2007.

METHODS: Forecast models were used to estimate possible trends of disease incidence. A homeoprophylactic formulation was prepared from dilutions of four circulating strains of Leptospirosis. This formulation was administered orally to 2.3 million persons at high risk in an epidemic in a region affected by natural disasters. The data from surveillance were used to measure the impact of the intervention by comparing with historical trends and non-intervention regions.

RESULTS: After the homeoprophylactic intervention a significant decrease of the disease incidence was observed in the intervention regions. No such modifications were observed in non-intervention regions. In the intervention region the incidence of Leptospirosis fell below the historic median. This observation was independent of rainfall.

CONCLUSIONS: The homeoprophylactic approach was associated with a large reduction of disease incidence and control of the epidemic. The results suggest the use of HP as a feasible tool for epidemic control, further research is warranted. Read more here.

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 Use of the nosode Meningococcinum as a preventative against meningitis

Castro, D. & Nogueira, G. G. (1975). Use of the nosode Meningococcinum as a preventive against meningitis.

​Journal of the American Institute of Homœopathy, 1975 Dec 68(4), 211-219 (not indexed on pubmed at this time)

Abstract: A campaign was made in Guaratingueta, a city in the State of San Paulo, Brazil, in August, 1974. 18,640 persons were immunised, with 6,340 children not being covered. The product used for immunisation was the nosode Meningococcinum 10CH, in a single dose.

For the analysis of the results, a comparison was made of the occurrence of meningitis during the months from August 1974 up to February 1975, in the immunised and non-immunised groups of the city. For the statistical analysis the Pearson’s X2 test was employed.

The following results were obtained: 18,640 protected homoeopathically 4 cases 6,340 not protected 32 cases. Based on the attack rate in the unprotected group, 94 cases would have been expected in the homoeopathically protected group. There were only 4, showing that the homœopathic option was 95% effective.

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​Menigococcinum: Its protective effect against meningococcal disease

Mroninski C, Adriano E & Mattos G (1998/99)

Homœopathic Links, Vol 14 Winter 2001, 230-234

Abstract: A report on a Government funded initiative in the city of Blumenau in the north of Santa Catarina State in Brazil conducted by senior medical staff. The study relates to the use of the nosode Meningococcinum 30CH on 65,826 people from 0 – 20 years of age in 1998 with a control group of 23,532.

The results were statistically significant, offering a protection against Meningococcal Disease of 95% in six months and 91% in a year.

​Credentials of the authors: Cleber R.L. MRONINSKI Specialist Physician in Public Health, Professor of the Medical Clinic Department at University Foundation in Blumenau Edson Jose ADRIANO Specialist Physician in Work Medicine, Health City Secretary in Blumenau Gerson MATTOS Homœopath, Specialist in Community and General Medicine, Professor of the Medical Clinic at the University Foundation in Blumenau Rua Waldir Medeiros 122 Bairro Vellha Blumenau 89042-340 Brazil

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Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal rodent malaria parasite: Plasmodium berghei

​ Aswathy Rajan, Upma Bagai

Journal of Complementary and Integrative Medicine

Published Online: 2013-06-15 | DOI: https://doi.org/10.1515/jcim-2012-0016

Abstract: Homeopathy is a therapeutic method based on the application of similia principle, utilizing ultra-low doses of medicinal substances made from natural products. The present study has been designed to evaluate the efficacy of Cinchona officinalis (Chin.) 30C and Chelidonium majus (Chel.) 30C in combination therapy against lethal murine malaria.

Five groups having twelve BALB/c mice each were administered orally with 0.2 ml/mouse/day of different drugs, and their antimalarial potential was evaluated by Peter’s 4-day test.

The combination of Chin. 30 and Chel. 30 exhibited complete parasite clearance by the 28th day post-inoculation which was similar to the positive control [artesunate (4 mg/kg)+sulphadoxine-primethamine (1.2 mg/kg)] group.

Both the groups exhibited enhanced mean survival time (MST) 28±0 days,whereas, the mice of infected control group survived up to 7.6±0.4 days only. The preventive and curative activities of the combination in comparison to the positive controls [pyrimethamine (1.2 mg/Kg) and chloroquine (20 mg/Kg), respectively] were also evaluated.

The combination had a significant preventive activity (p<0.0005), with 89.2% chemosuppression which was higher than the standard drug, pyrimethamine (83.8%). It also showed a moderate curative activity with complete clearance of parasite in 50% of surviving mice, and enhancing the MST of mice up to 26.8±2.8 days.

These findings point to the significant antiplasmodial efficacy of the combination of these homeopathic drugs against Plasmodium berghei. Read more here.

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Action of antibiotic oxacillin on in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) previously treated with homeopathic medicines

Homeopathy. 2017 Feb;106(1):27-31. doi: 10.1016/j.homp.2016.10.002. Epub 2016 Dec 3. 
Passeti TA1, Bissoli LR2, Macedo AP3, Libame RB4, Diniz S5, Waisse S6.Author information1
ABC Medical School of Santo André, Rua Principe de Gales, 821 Santo André, Brazil. Electronic address: tania.passeti@japta.com.br.

Abstract
BACKGROUND:

Resistance to antibiotics is a major public health concern worldwide. New treatment options are needed and homeopathy is one such option. We sought to assess the effect of the homeopathic medicine Belladonna (Bell) and a nosode (biotherapy) prepared from a multi-drug resistant bacterial species, methicillin-resistant Staphylococcus aureus (MRSA), on the same bacterium.

METHODS: Bell and MRSA nosode were prepared in 6cH and 30cH potencies in 30% alcohol and sterile water, according to the Brazilian Homeopathic Pharmacopeia and tested on MRSA National Collection of Type Cultures (NCTC) 10442. We assessed in vitro bacterial growth, deoxyribonuclease (DNAase) and hemolysin activity, and in vitro bacterial growth in combination with oxacillin (minimum inhibitory concentration - MIC). All values were compared to control: 30% alcohol and water.

RESULTS:In vitro growth of MRSA was statistically significantly inhibited in the presence of Bell and nosode 6cH and 30cH compared to controls (p < 0.0001); and with combination of Bell or nosode 6cH and 30cH and oxacillin (p < 0.001). Bell 30cH and nosode 6cH and 30cH significantly decreased bacterial DNAse production (p < 0.001) and reduced red blood cell lysis.

CONCLUSIONS:Cultures of MRSA treated with Belladonna or MRSA nosode exhibited reduced growth in vitro, reduced enzymatic activity and became more vulnerable to the action of the antibiotic oxacillin. Further studies are needed on the biomolecular basis of these effects. Read more here...

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Homeopathic medicines for prevention of influenza and acute respiratory tract infections in children: blind, randomized, placebo-controlled clinical trial. ​

Homeopathy. 2016 Feb;105(1):71-7. doi: 10.1016/j.homp.2015.02.006. Epub 2015 Aug 4.

Siqueira CM1, Homsani F2, da Veiga VF3, Lyrio C4, Mattos H5, Passos SR6, Couceiro JN3, Quaresma CH7

BACKGROUND: Influenza and its complications are common at all ages, especially in children. Vaccines and anti-influenza drugs aim to prevent it. Preventative approaches with favorable risk profiles should be considered for flu, particularly since the evidence of the efficacy of anti-viral drugs is debated. 

METHODS: This pragmatic clinical trial was conducted in the Brazilian Public Health System in Petrópolis (BPHSP) with children aged from 1 to 5 years old. The medications used were mainly selected based on in vitro experiments (InfluBio), and in successful qualitative clinical experiences (Homeopathic Complex).  

Following informed parental consent, subjects were randomly distributed, in a blind manner, to three experimental groups: Homeopathic Complex, Placebo, and InfluBio. BPHSP health agents collected flu and acute respiratory infection symptomatic episodes monthly following the established protocol. The number of these episodes was registered in one year (2009-2010).

RESULTS:Out of the 600 children recruited, 445 (74.17%) completed the study (149: Homeopathic complex; 151: Placebo; 145: InfluBio). The number of flu and acute respiratory infection symptomatic episodes detected in this clinical trial was low; however, it was different between homeopathic groups and placebo (p < 0.001).

In the first year post-intervention, 46/151 (30.5%) of children in the placebo group developed 3 or more flu and acute respiratory infection episodes, while there was no episode in the group of 149 children who used Homeopathic Complex, and only 1 episode in the group of 145 (1%) children who received InfluBio.

CONCLUSION: These results suggested that the use of homeopathic medicines minimized the number of flu and acute respiratory infection symptomatic episodes in children, signalizing that the homeopathic prophylactic potential should be investigated in further studies. Read more here...

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Does homeopathic medicine have a preventive effect on respiratory tract infections? A real life observational study.

Multidiscip Respir Med. 2016 Mar 21;11:12. doi: 10.1186/s40248-016-0049-0. eCollection 2016.  

Beghi GM, Morselli-Labate AM

​BACKGROUND:Homeopathic medicine is a branch of integrative medicine that has been gaining increasing popularity. However, its clinical application remains controversial. To improve the understanding of homeopathy, observational studies-which monitor the effects of homeopathy in real-life clinical settings-are a helpful adjunct to randomized controlled trials.

The goal of this controlled observational study was to investigate the role of the homeopathic medicine in preventing respiratory tract infections (RTIs).METHODS:This retrospective analysis of patients' medical records focused on a single centre from 2002 to 2011, and examined 459 patients, out of whom 248 were treated with homeopathic medicine (specific extract of duck liver and heart) and 211 were not treated. All patients were followed-up for at least 1 year, and up to a maximum of 10 years.

RESULTS:

A significant reduction in the frequency of onset of RTIs was found in both the homeopathic medicine and untreated groups. The reduction in the mean number of RTI episodes during the period of observation vs. the year before inclusion in the study was significantly greater in the homeopathic-treated group than in untreated patients (-4.76 ± 1.45 vs. -3.36 ± 1.30; p = 0.001). The beneficial effect of the homeopathic medicine was not significantly related to gender, age, smoking habits or concomitant respiratory diseases when compared to the effect observed in untreated patients.

CONCLUSION:

These results suggest that homeopathic medicine may have a positive effect in preventing RTIs. However, randomized studies are needed before any firm conclusion can be reached. Read more here...

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Homeopathy outperforms antibiotics treatment in juvenile scallop Argopecten ventricosus: effects on growth, survival, and immune response

José Manuel Mazón-Suástegui, Milagro García-Bernal, Pedro Enrique Saucedo, Ángel Campa-Córdova, Fernando Abasolo-Pacheco, Homeopathy (Journal) , February 2017, Volume 106, Issue 1, Pages 18–26 Read the abstract here.

This was a study done on scallops. Scallops can die from certain types of bacteria, including Vibrio alginolyticus. Use of increasingly potent antibiotics has led to bacterial resistance and increased pathogenicity. Alternatives in sanitation, safety, and environmental sustainability are currently under analysis. To-date, homeopathy has been investigated in aquaculture of freshwater fish, but not in marine mollusks. The effect of the homeopathic complexes in the growth, survival, and immune response of the Catarina scallop Argopecten ventricosus were assessed.

The study found that:

• Two homeopathic complexes improved performance in juvenile scallop A. ventricosus (they grew bigger and faster and were more resistant to the pathogenic bacteria.)
• Homeopathic complexes included Phosphoric acidum (TH1) and Silicea terra (TH2).
• TH1 enhanced immune response in juvenile scallops against Vibrio alginolyticus.
• TH2 improved growth and enhanced protein content in juvenile scallops.
• Homeopathy is innocuous, eco-friendly, and outperforms antibiotics.

Conclusions

Homeopathic treatments improved growth and survival and enhanced survival against V. alginolyticus in juvenile A. ventricosus. This suggests that homeopathy is a viable treatment for this mollusk to reduce use of antibiotics in scallops and its progressive increase in pathogenicity in mollusk hatcheries. Read more here...

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Prophylactic Efficacy of Homoeopathy in Chikungunya

A Study on the Prophylactic Efficacy of Homoeopathic Preventive Medicine Against Chikungunya Fever
Dr R Rejikumar, Dr R S Dinesh etal

The study was conducted in the Chikungunya fever hit areas of Kerala. The genus epidemicus was selected after detailed analysis of the first cases of Chikungunya. This preventive medicine was widely distributed in the disease prevalent areas. A survey was conducted for the evaluation of prophylactic efficacy. The study showed a very high significant effect of Homoeopathic medicine in the prevention of Chikungunya fever.

Key words : Homoeopathy, Prophylaxis, Genus Epidemicus, Chikungunya fever

Summary: An outbreak of Chikungunya fever in Kerala, India, was successfully controlled with a homeopathic remedy of the genus epidemicus, in this case, Eupatorium. The treatment was about 80% effective at preventing the disease. 

Chikungunya is a relatively rare form of viral fever caused by an alphavirus that is spread by mosquito bites from the Aedes aegypti mosquito, though recent research by the Pasteur Institute in Paris claims the virus has suffered a mutation that enables it to be transmitted by Aedes Albopictus (Tiger mosquito).

The name is derived from the Makonde word meaning “that which bends up” in reference to the stooped posture developed as a result of the arthritic symptoms of the disease. 

Chikungunya is not considered to be fatal. However, in 2005-2006, 200 deaths were associated with chikungunya on Réunion island and a widespread outbreak in Kerala.

Aims & Objectives
1. To assess the efficacy of Homoeopathic medicine in the prevention of Chikungunya.
2. To determine the magnitude of incidence, clinical features, mortality , social & economic impact of the Chikungunya epidemic.

Materials & Methods
After detailed analysis of Chikungunya cases in Neyyattinkara & Vizhinjam, the Genus epidemicus was selected to be Eupatorium perfoliatum. The 200th centesimal potency of this medicine was given in 15 doses (3 doses daily for 5 consecutive days). 

Download the full study report : www.homeobook.com/pdf/efficacy-chiunguna-kerala.pdf

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Prophylactic Effect on Animal Viruses

 Singh L.M., Gupta G. Antiviral Efficacy of Homeopathic Drugs against Animal Viruses. British Homeopathic Journal, 1985, July, 74, 168-174. 
Researchers at the Indian Central Drug Research Institute in Lucknow carried out this study to determine the inhibiting effects, if any, of various potencies of 10 homeopathic remedies on chicken embryo virus and simliki forest virus, a virus capable of causing encephalitis, paralysis ad death in mice. Homeopathic typhoidinum 200C, hydrophobinum 1M, tuberculinum 1M, nux vomica 200C and malandrinum 1M all produced 100% inhibition of the chicken embryo virus. Read more here...